Transdermal selegiline, an irreversible selective monoamine oxidase B (MAO-B) inhibitor, is approved as an antidepressant in the USA
An increase in tyramine sensitivity for blood pressure responses appears to begin at a dose of 5 mg ZELAPAR daily [see
Selegiline and rasagiline can also be taken alone as initial therapy for patients with mild motor symptoms of Parkinson disease
Emsam (selegiline) patch can interact with many prescriptions, over-the-counter, and herbal medications, so make sure your provider is aware of all the
Parkinson's disease is a complicated disease state that affects patients' quality of life
The STS may also play a role in the treatment of atypical depression, treatment resistant MDD, and anxiety disorders
It is the L-form of selegiline that is an active MAO-B inhibitor, the D- (+)-form being 25 times less active
Some owners may notice improvement in three weeks or less, but many dogs can take six weeks before showing changes
Zydis selegiline (Zelapar) is an orally disintegrating formation of selegiline and absorbed from the buccal mucosa, increased plasma level, and decreased MAO-A PET image detected with [11 C]clorgyline in human brain
By contrast, oral dosing produced a sharp plasma selegiline peak that occurred within 1 hour and declined rapidly, with an absolute bioavailability of 4%
The use of selegiline in dogs has improved cognitive ability in geriatric dogs, as well as increasing their quality of life and longevity
The study used a double-blind randomized three-arm parallel-groups design with a 2-week placebo baseline followed by 6 weeks of treatment (placebo, 20 mg/day, or 60 mg/day selegiline) and then by 2 Selegiline (1-deprenyl) is an irreversible inhibitor of monoamine oxidase (MAO) type B